Effects of Nebracetam (WEB 1881 FU), a Novel Nootropic, as a Mi-Muscarinic Agonist

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Effects of WEB 1881 FU, a novel nootropic, on cholinergic and adrenergic receptors in the rat brain: action on M1-muscarinic receptors.

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Central cholinergic hypofunction causes the disruption of spatial cognition, while cholinomimetics improve this disruption in rats. Scopolamine (0.5 mg/kg, i.p.) has also been reported to disrupt radial maze performance in rats. Nebracetam (WEB 1881 FU), a new nootropic candidate, was able to correct this scopolamine-induced disruption of spatial cognition at the dose of 10 mg/kg, p.o. Furtherm...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1991

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)52085-6